fenproporex ( esbelcaps, diety)
fenproporex ( esbelcaps, diety) (3-[(2-methyl-1-phenylpropan-2-yl)amino]propanenitrile), a compound structurally similar to amphetamine, was developed as an anorectic drug in the 1960s.
A systematic search in MEDLINE, LILACS, and the Cochrane Controlled Trials Register (CCTR) databases was conducted using the search string fenproporex (OR femproporex). The search covered the time period from the inception of each electronic database until February 4, 2015. To identify studies of interest for this review that were published in non-indexed journals, the authors also examined reference lists of original and review articles as well as reports and therapeutic guidelines issued by medical associations and regulatory agencies. To be accepted for analysis, a clinical trial had to be a placebo-controlled study on FEN safety and efficacy in the management of overweight or obesity (BMI > 30 kg/m2) of adolescent or adult, male or female patients. No restriction regarding duration of the trial was imposed.